Capreomycin + Dexamethasone-tobramycin

MediHelp rates the interaction as major. Capreomycin and Dexamethasone-tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Capreomycin and aminoglycosides such as tobramycin are both nephrotoxic, ototoxic and may cause neuromuscular blockade. Combined use raises the risk of renal impairment, hearing loss and vestibular damage. Systemic exposure from ophthalmic tobramycin is low, but risk increases with systemic use.

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent systemic use where possible; otherwise monitor serum creatinine, drug levels and audiometry regularly.

MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Carboplatin, Ciprofloxacin, Cisplatin. The full list is on the Dexamethasone-tobramycin page.