تداخل‌های دارویی
Captopril-hydrochlorothiazide + Sacubitril / valsartan
شدت: منع مصرف
Captopril-hydrochlorothiazide and Sacubitril / valsartan: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Neprilysin inhibition by sacubitril together with ACE inhibition impairs bradykinin breakdown and substantially raises the risk of angioedema, which can be life-threatening. Additional valsartan effects add to hypotension, hyperkalemia and renal risks.
معنای این تداخل به زبان ساده
Captopril-hydrochlorothiazide and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
چرا رخ می‌دهد
Concurrent inhibition of neprilysin and ACE reduces bradykinin degradation, causing excess bradykinin-mediated angioedema.
اقدام لازم
Never give together; allow at least 36 hours between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Captopril-hydrochlorothiazide و Sacubitril / valsartan، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Captopril-hydrochlorothiazide
پرسش‌های متداول
Can I take Captopril-hydrochlorothiazide with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Captopril-hydrochlorothiazide and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Neprilysin inhibition by sacubitril together with ACE inhibition impairs bradykinin breakdown and substantially raises the risk of angioedema, which can be life-threatening. Additional valsartan effects add to hypotension, hyperkalemia and renal risks.
How serious is the interaction between Captopril-hydrochlorothiazide and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never give together; allow at least 36 hours between the last ACE inhibitor dose and the first sacubitril/valsartan dose, and vice versa.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Aceclofenac. The full list is on the Captopril-hydrochlorothiazide page.
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مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
