تداخل‌های دارویی
Carbamazepine + Sofosbuvir-velpatasvir
شدت: شدید
Carbamazepine and Sofosbuvir-velpatasvir: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Carbamazepine is a potent inducer of P-glycoprotein and of several CYP enzymes, and it can substantially lower plasma concentrations of sofosbuvir and velpatasvir. This may lead to loss of antiviral activity and treatment failure or resistance. The combination is not recommended in labeling.
معنای این تداخل به زبان ساده
Carbamazepine and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Sofosbuvir-velpatasvir belongs to Anti Virals.
چرا رخ می‌دهد
Carbamazepine induces P-gp and CYP2B6, CYP2C8 and CYP3A4, increasing clearance and reducing absorption of sofosbuvir and velpatasvir.
اقدام لازم
Avoid the combination and switch to an anticonvulsant without enzyme-inducing activity, such as levetiracetam, if clinically possible. If it cannot be avoided, consult a hepatology or infectious disease specialist and confirm sustained virologic response.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Carbamazepine و Sofosbuvir-velpatasvir، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Sofosbuvir-velpatasvir
تداخلات دیگر Carbamazepine
- Artemether / lumefantrine + Carbamazepine منع مصرف
- Cabotegravir + Carbamazepine منع مصرف
- Carbamazepine + Delamanid منع مصرف
- Carbamazepine + Dienogest / estradiol valerate منع مصرف
- Carbamazepine + Doravirine منع مصرف
- Carbamazepine + Elbasvir / grazoprevir منع مصرف
پرسش‌های متداول
Can I take Carbamazepine with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as major. Carbamazepine and Sofosbuvir-velpatasvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine is a potent inducer of P-glycoprotein and of several CYP enzymes, and it can substantially lower plasma concentrations of sofosbuvir and velpatasvir. This may lead to loss of antiviral activity and treatment failure or resistance. The combination is not recommended in labeling.
How serious is the interaction between Carbamazepine and Sofosbuvir-velpatasvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and switch to an anticonvulsant without enzyme-inducing activity, such as levetiracetam, if clinically possible. If it cannot be avoided, consult a hepatology or infectious disease specialist and confirm sustained virologic response.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
