تداخل‌های دارویی
Chloramphenicol + Vitamin B12
شدت: متوسط
Chloramphenicol and Vitamin B12: moderate interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Chloramphenicol can suppress bone marrow, which may delay or blunt the hematologic response to vitamin B12 in patients being treated for pernicious or megaloblastic anemia. The effect is described in case reports and has clinical relevance mainly in deficient patients.
معنای این تداخل به زبان ساده
Chloramphenicol and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloramphenicol belongs to Anti Bacterial; Vitamin B12 belongs to Gastrointestinal Tract.
چرا رخ می‌دهد
Chloramphenicol-induced bone marrow suppression counteracts the erythropoietic response to B12 replacement.
اقدام لازم
Monitor reticulocyte count and hemoglobin in B12-deficient patients receiving chloramphenicol. Use an alternative antibiotic if the expected hematologic response fails to appear.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Chloramphenicol و Vitamin B12، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Vitamin B12
تداخلات دیگر Chloramphenicol
پرسش‌های متداول
Can I take Chloramphenicol with Vitamin B12?
MediHelp rates the interaction as moderate. Chloramphenicol and Vitamin B12 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol can suppress bone marrow, which may delay or blunt the hematologic response to vitamin B12 in patients being treated for pernicious or megaloblastic anemia. The effect is described in case reports and has clinical relevance mainly in deficient patients.
How serious is the interaction between Chloramphenicol and Vitamin B12?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor reticulocyte count and hemoglobin in B12-deficient patients receiving chloramphenicol. Use an alternative antibiotic if the expected hematologic response fails to appear.
What other medicines interact with Vitamin B12?
MediHelp also lists interactions of Vitamin B12 with, for example, Dichlorphenamide, Metformin, Neomycin po. The full list is on the Vitamin B12 page.
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