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Chlorpromazine + Metrizamide

شدت: منع مصرف

Chlorpromazine and Metrizamide: contraindicated interaction.

آخرین به‌روزرسانی

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خلاصه

Intrathecal metrizamide lowers the seizure threshold, and phenothiazines such as chlorpromazine also lower it. Giving them together raises the risk of convulsions after myelography.

معنای این تداخل به زبان ساده

Chlorpromazine and Metrizamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive lowering of the seizure threshold; the precise mechanism is not well established.

اقدام لازم

Stop the phenothiazine at least 48 hours before myelography where feasible, and do not restart it for at least 24 hours afterwards. Use a non-ionic contrast agent suited to intrathecal use, and avoid this combination.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Chlorpromazine و Metrizamide، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Chlorpromazine with Metrizamide?

MediHelp rates the interaction as contraindicated. Chlorpromazine and Metrizamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intrathecal metrizamide lowers the seizure threshold, and phenothiazines such as chlorpromazine also lower it. Giving them together raises the risk of convulsions after myelography.

How serious is the interaction between Chlorpromazine and Metrizamide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop the phenothiazine at least 48 hours before myelography where feasible, and do not restart it for at least 24 hours afterwards. Use a non-ionic contrast agent suited to intrathecal use, and avoid this combination.

What other medicines interact with Chlorpromazine?

MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.

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