تداخل‌های دارویی
Cholera vaccine + Cladribine
شدت: شدید
Cholera vaccine and Cladribine: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cladribine causes prolonged lymphocyte depletion, which can reduce the immune response to vaccines. The oral cholera vaccine is live attenuated, so there is also a theoretical risk of infection from the vaccine strain.
معنای این تداخل به زبان ساده
Cholera vaccine and Cladribine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Cladribine-induced lymphopenia impairs vaccine immune responses and may permit replication of a live attenuated vaccine strain.
اقدام لازم
Avoid live vaccines during and after cladribine until lymphocyte counts have recovered. Where possible, complete vaccination at least 4 to 6 weeks before starting cladribine.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cholera vaccine و Cladribine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cladribine
پرسش‌های متداول
Can I take Cholera vaccine with Cladribine?
MediHelp rates the interaction as major. Cholera vaccine and Cladribine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cladribine causes prolonged lymphocyte depletion, which can reduce the immune response to vaccines. The oral cholera vaccine is live attenuated, so there is also a theoretical risk of infection from the vaccine strain.
How serious is the interaction between Cholera vaccine and Cladribine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during and after cladribine until lymphocyte counts have recovered. Where possible, complete vaccination at least 4 to 6 weeks before starting cladribine.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Adenovirus types 4 and 7 live, Siponimod, Tofacitinib. The full list is on the Cladribine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
