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Cimetidine + Pefloxacin

شدت: متوسط

Cimetidine and Pefloxacin: moderate interaction.

آخرین به‌روزرسانی

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خلاصه

Cimetidine has been reported to slow pefloxacin elimination, raising its levels and half-life. Increased fluoroquinolone adverse effects such as CNS effects are possible but this is rarely significant.

معنای این تداخل به زبان ساده

Cimetidine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cimetidine belongs to Gastrointestinal Tract; Pefloxacin belongs to Anti Bacterial.

سطح شواهد: Low

چرا رخ می‌دهد

Cimetidine inhibits hepatic oxidative metabolism of pefloxacin, reducing its clearance.

اقدام لازم

Monitor for CNS effects and tendon or gastrointestinal adverse effects, and consider lowering the pefloxacin dose in hepatic impairment or the elderly.

از داروساز چه بپرسید

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cimetidine و Pefloxacin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Cimetidine with Pefloxacin?

MediHelp rates the interaction as moderate. Cimetidine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine has been reported to slow pefloxacin elimination, raising its levels and half-life. Increased fluoroquinolone adverse effects such as CNS effects are possible but this is rarely significant.

How serious is the interaction between Cimetidine and Pefloxacin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for CNS effects and tendon or gastrointestinal adverse effects, and consider lowering the pefloxacin dose in hepatic impairment or the elderly.

What other medicines interact with Cimetidine?

MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.

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