تداخل‌های دارویی
Ciprofloxacin + Fezolinetant
شدت: منع مصرف
Ciprofloxacin and Fezolinetant: contraindicated interaction.
آخرین به‌روزرسانی
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خلاصه
Ciprofloxacin is a moderate CYP1A2 inhibitor, and fezolinetant is mainly cleared by CYP1A2. Coadministration raises fezolinetant exposure and may increase risk of adverse effects including liver enzyme elevations.
معنای این تداخل به زبان ساده
Ciprofloxacin and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ciprofloxacin belongs to Anti Bacterial; Fezolinetant belongs to Endocrine.
چرا رخ می‌دهد
Inhibition of CYP1A2-mediated metabolism of fezolinetant by ciprofloxacin.
اقدام لازم
Do not use together as per fezolinetant labeling. Choose a non-CYP1A2-inhibiting antibiotic or hold fezolinetant during the short course.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Ciprofloxacin و Fezolinetant، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Ciprofloxacin
- Agomelatine + Ciprofloxacin منع مصرف
- Ciprofloxacin + Thioridazine منع مصرف
- Ciprofloxacin + Tizanidine منع مصرف
- Ciprofloxacin + Vandetanib منع مصرف
- Alosetron + Ciprofloxacin شدید
- Aluminum hydroxide + Ciprofloxacin شدید
تداخلات دیگر Fezolinetant
پرسش‌های متداول
Can I take Ciprofloxacin with Fezolinetant?
MediHelp rates the interaction as contraindicated. Ciprofloxacin and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ciprofloxacin is a moderate CYP1A2 inhibitor, and fezolinetant is mainly cleared by CYP1A2. Coadministration raises fezolinetant exposure and may increase risk of adverse effects including liver enzyme elevations.
How serious is the interaction between Ciprofloxacin and Fezolinetant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together as per fezolinetant labeling. Choose a non-CYP1A2-inhibiting antibiotic or hold fezolinetant during the short course.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Thioridazine, Tizanidine. The full list is on the Ciprofloxacin page.
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