رفتن به محتوا

تداخل‌های دارویی

Clarithromycin + Dihydroergotamine intranasal

شدت: منع مصرف

Clarithromycin and Dihydroergotamine intranasal: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Even with intranasal use, systemic exposure to dihydroergotamine is sufficient that strong CYP3A4 inhibition by clarithromycin can cause ergotism, with severe vasospasm and ischemia of extremities and the CNS.

معنای این تداخل به زبان ساده

Clarithromycin and Dihydroergotamine intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: High

چرا رخ می‌دهد

Clarithromycin inhibits CYP3A4 and decreases clearance of dihydroergotamine.

اقدام لازم

Do not coadminister; use an alternative antibiotic such as azithromycin and advise patients to report cold, numb or painful extremities immediately.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clarithromycin و Dihydroergotamine intranasal، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Clarithromycin with Dihydroergotamine intranasal?

MediHelp rates the interaction as contraindicated. Clarithromycin and Dihydroergotamine intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Even with intranasal use, systemic exposure to dihydroergotamine is sufficient that strong CYP3A4 inhibition by clarithromycin can cause ergotism, with severe vasospasm and ischemia of extremities and the CNS.

How serious is the interaction between Clarithromycin and Dihydroergotamine intranasal?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibiotic such as azithromycin and advise patients to report cold, numb or painful extremities immediately.

What other medicines interact with Clarithromycin?

MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.

تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp

مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.

مرور از A تا Z · تداخل‌های دارویی

دریافت برنامه ورود