تداخل‌های دارویی
Clarithromycin + Tolterodine
شدت: شدید
Clarithromycin and Tolterodine: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Clarithromycin is a strong CYP3A4 inhibitor and raises tolterodine exposure, particularly in CYP2D6 poor metabolizers. Increased levels may enhance anticholinergic effects and QT prolongation risk, and both drugs have QT liability.
معنای این تداخل به زبان ساده
Clarithromycin and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Tolterodine belongs to Genitourinary.
چرا رخ می‌دهد
Strong CYP3A4 inhibition by clarithromycin reduces tolterodine metabolism, with additive QT effects.
اقدام لازم
Limit tolterodine to 2 mg daily (1 mg twice daily for IR) during co-treatment, or use an alternative antibiotic such as azithromycin; monitor ECG in patients with QT risk factors.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clarithromycin و Tolterodine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Tolterodine
تداخلات دیگر Clarithromycin
- Astemizole + Clarithromycin منع مصرف
- Avanafil + Clarithromycin منع مصرف
- Cisapride + Clarithromycin منع مصرف
- Clarithromycin + Colchicine منع مصرف
- Clarithromycin + Conivaptan منع مصرف
- Clarithromycin + Dihydroergotamine منع مصرف
پرسش‌های متداول
Can I take Clarithromycin with Tolterodine?
MediHelp rates the interaction as major. Clarithromycin and Tolterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin is a strong CYP3A4 inhibitor and raises tolterodine exposure, particularly in CYP2D6 poor metabolizers. Increased levels may enhance anticholinergic effects and QT prolongation risk, and both drugs have QT liability.
How serious is the interaction between Clarithromycin and Tolterodine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit tolterodine to 2 mg daily (1 mg twice daily for IR) during co-treatment, or use an alternative antibiotic such as azithromycin; monitor ECG in patients with QT risk factors.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clozapine, Cobicistat, Dronedarone. The full list is on the Tolterodine page.
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