تداخل‌های دارویی
Clarithromycin + Vincristine
شدت: شدید
Clarithromycin and Vincristine: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Clarithromycin can raise vincristine levels and increase the risk of severe neurotoxicity, including neuropathy, ileus and seizures. Cases of enhanced toxicity have been described with strong CYP3A4 inhibitors.
معنای این تداخل به زبان ساده
Clarithromycin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Vincristine belongs to Oncology.
چرا رخ می‌دهد
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux of vincristine by clarithromycin.
اقدام لازم
Avoid concomitant use and choose an alternative antibiotic such as azithromycin. If it cannot be avoided, monitor closely for neuropathy, constipation and CNS toxicity.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clarithromycin و Vincristine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Clarithromycin
- Astemizole + Clarithromycin منع مصرف
- Avanafil + Clarithromycin منع مصرف
- Cisapride + Clarithromycin منع مصرف
- Clarithromycin + Colchicine منع مصرف
- Clarithromycin + Conivaptan منع مصرف
- Clarithromycin + Dihydroergotamine منع مصرف
تداخلات دیگر Vincristine
پرسش‌های متداول
Can I take Clarithromycin with Vincristine?
MediHelp rates the interaction as major. Clarithromycin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin can raise vincristine levels and increase the risk of severe neurotoxicity, including neuropathy, ileus and seizures. Cases of enhanced toxicity have been described with strong CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use and choose an alternative antibiotic such as azithromycin. If it cannot be avoided, monitor closely for neuropathy, constipation and CNS toxicity.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
