تداخل‌های دارویی
Clindamycin + Rapacuronium
شدت: شدید
Clindamycin and Rapacuronium: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Clindamycin has intrinsic neuromuscular blocking activity and can potentiate non-depolarizing neuromuscular blockers. This may prolong paralysis and cause delayed respiratory depression. Rapacuronium has been withdrawn from the market in most countries, so this is mainly of historical relevance.
معنای این تداخل به زبان ساده
Clindamycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Clindamycin has additive pre- and postsynaptic neuromuscular blocking effects that potentiate non-depolarizing blockade.
اقدام لازم
Avoid the combination where possible. If a neuromuscular blocker and clindamycin must be given together, use quantitative neuromuscular monitoring and have ventilatory support available until full recovery is confirmed.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clindamycin و Rapacuronium، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Clindamycin
پرسش‌های متداول
Can I take Clindamycin with Rapacuronium?
MediHelp rates the interaction as major. Clindamycin and Rapacuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clindamycin has intrinsic neuromuscular blocking activity and can potentiate non-depolarizing neuromuscular blockers. This may prolong paralysis and cause delayed respiratory depression. Rapacuronium has been withdrawn from the market in most countries, so this is mainly of historical relevance.
How serious is the interaction between Clindamycin and Rapacuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If a neuromuscular blocker and clindamycin must be given together, use quantitative neuromuscular monitoring and have ventilatory support available until full recovery is confirmed.
What other medicines interact with Clindamycin?
MediHelp also lists interactions of Clindamycin with, for example, Atracurium, Cisatracurium, Microbiota. The full list is on the Clindamycin page.
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