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تداخل‌های دارویی

Clobazam + Clozapine

شدت: شدید

Clobazam and Clozapine: major interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Both agents depress the CNS, so combining them can cause excessive sedation, and benzodiazepines with clozapine have been associated with respiratory depression and collapse. The risk is highest at initiation or after dose increases.

معنای این تداخل به زبان ساده

Clobazam and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clobazam belongs to Central Nervous System; Clozapine belongs to Central Nervous System.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive CNS and respiratory depression through GABA-A potentiation and clozapine's sedative actions.

اقدام لازم

Use the lowest effective doses and titrate slowly, monitoring sedation, blood pressure and respiratory status. Avoid starting both together.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clobazam و Clozapine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Clobazam with Clozapine?

MediHelp rates the interaction as major. Clobazam and Clozapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents depress the CNS, so combining them can cause excessive sedation, and benzodiazepines with clozapine have been associated with respiratory depression and collapse. The risk is highest at initiation or after dose increases.

How serious is the interaction between Clobazam and Clozapine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate slowly, monitoring sedation, blood pressure and respiratory status. Avoid starting both together.

What other medicines interact with Clozapine?

MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.

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