تداخل‌های دارویی
Clozapine + Darifenacin
شدت: شدید
Clozapine and Darifenacin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Both drugs have anticholinergic activity, and clozapine already causes constipation that can progress to severe gastrointestinal hypomotility or ileus. Adding darifenacin raises the risk of constipation, urinary retention, tachycardia and cognitive effects. Darifenacin may also modestly increase clozapine exposure by CYP2D6 inhibition.
معنای این تداخل به زبان ساده
Clozapine and Darifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Darifenacin belongs to Genitourinary.
چرا رخ می‌دهد
Additive antimuscarinic effects, with possible CYP2D6 inhibition by darifenacin raising clozapine levels.
اقدام لازم
Avoid the combination where possible, or monitor bowel function closely and treat constipation early. Review the need for darifenacin and reduce the clozapine dose if toxicity occurs.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Clozapine و Darifenacin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Darifenacin
تداخلات دیگر Clozapine
- Clozapine + Deferiprone منع مصرف
- Clozapine + Irinotecan منع مصرف
- Clozapine + Pimozide منع مصرف
- Clozapine + Thioridazine منع مصرف
- Acalabrutinib + Clozapine شدید
- Adagrasib + Clozapine شدید
پرسش‌های متداول
Can I take Clozapine with Darifenacin?
MediHelp rates the interaction as major. Clozapine and Darifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have anticholinergic activity, and clozapine already causes constipation that can progress to severe gastrointestinal hypomotility or ileus. Adding darifenacin raises the risk of constipation, urinary retention, tachycardia and cognitive effects. Darifenacin may also modestly increase clozapine exposure by CYP2D6 inhibition.
How serious is the interaction between Clozapine and Darifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor bowel function closely and treat constipation early. Review the need for darifenacin and reduce the clozapine dose if toxicity occurs.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
