تداخل‌های دارویی
Colchicine + Ritonavir
شدت: منع مصرف
Colchicine and Ritonavir: contraindicated interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Ritonavir substantially increases colchicine exposure, and life-threatening or fatal colchicine toxicity has been reported. Toxicity may include severe gastrointestinal illness, rhabdomyolysis, pancytopenia and multiorgan failure. The combination is contraindicated in patients with renal or hepatic impairment and requires major dose reduction in others.
معنای این تداخل به زبان ساده
Colchicine and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Colchicine belongs to Genitourinary; Ritonavir belongs to Anti Virals.
چرا رخ می‌دهد
Ritonavir is a potent CYP3A4 and P-glycoprotein inhibitor, which markedly reduces colchicine clearance.
اقدام لازم
Do not combine in patients with renal or hepatic impairment. In patients with normal organ function where co-administration cannot be avoided, follow the labeled markedly reduced colchicine dosing and avoid repeating flare treatment for several days.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Colchicine و Ritonavir، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Colchicine
- Clarithromycin + Colchicine منع مصرف
- Cobicistat + Colchicine منع مصرف
- Colchicine + Cyclosporine منع مصرف
- Colchicine + Ensitrelvir منع مصرف
- Colchicine + Levoketoconazole منع مصرف
- Colchicine + Nirmatrelvir منع مصرف
تداخلات دیگر Ritonavir
- Alfuzosin + Ritonavir منع مصرف
- Amiodarone + Ritonavir منع مصرف
- Avanafil + Ritonavir منع مصرف
- Dronedarone + Ritonavir منع مصرف
- Eletriptan + Ritonavir منع مصرف
- Eplerenone + Ritonavir منع مصرف
پرسش‌های متداول
Can I take Colchicine with Ritonavir?
MediHelp rates the interaction as contraindicated. Colchicine and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir substantially increases colchicine exposure, and life-threatening or fatal colchicine toxicity has been reported. Toxicity may include severe gastrointestinal illness, rhabdomyolysis, pancytopenia and multiorgan failure. The combination is contraindicated in patients with renal or hepatic impairment and requires major dose reduction in others.
How serious is the interaction between Colchicine and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine in patients with renal or hepatic impairment. In patients with normal organ function where co-administration cannot be avoided, follow the labeled markedly reduced colchicine dosing and avoid repeating flare treatment for several days.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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