تداخل‌های دارویی
Conivaptan + Ketoconazole
شدت: منع مصرف
Conivaptan and Ketoconazole: contraindicated interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Ketoconazole markedly increases conivaptan exposure and the combination is contraindicated in labeling. Excess conivaptan can cause overly rapid rise in serum sodium, with risk of osmotic demyelination, as well as hypotension and infusion-site reactions. Patients with hyponatremia are most at risk.
معنای این تداخل به زبان ساده
Conivaptan and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
چرا رخ می‌دهد
Ketoconazole is a strong CYP3A4 inhibitor, and conivaptan is a CYP3A4 substrate, so clearance falls and exposure increases.
اقدام لازم
Do not use together. If an azole antifungal is needed, consider one without strong CYP3A4 inhibition, or select alternative hyponatremia therapy.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Conivaptan و Ketoconazole، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
تداخلات دیگر Ketoconazole
- Alfuzosin + Ketoconazole منع مصرف
- Alprazolam + Ketoconazole منع مصرف
- Avanafil + Ketoconazole منع مصرف
- Dihydroergotamine intranasal + Ketoconazole منع مصرف
- Dihydroergotamine + Ketoconazole منع مصرف
- Disopyramide + Ketoconazole منع مصرف
پرسش‌های متداول
Can I take Conivaptan with Ketoconazole?
MediHelp rates the interaction as contraindicated. Conivaptan and Ketoconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole markedly increases conivaptan exposure and the combination is contraindicated in labeling. Excess conivaptan can cause overly rapid rise in serum sodium, with risk of osmotic demyelination, as well as hypotension and infusion-site reactions. Patients with hyponatremia are most at risk.
How serious is the interaction between Conivaptan and Ketoconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. If an azole antifungal is needed, consider one without strong CYP3A4 inhibition, or select alternative hyponatremia therapy.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
