تداخل‌های دارویی
Cyclosporin + Tacrolimus
شدت: منع مصرف
Cyclosporin and Tacrolimus: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Both are calcineurin inhibitors and together they increase nephrotoxicity, neurotoxicity and over-immunosuppression. Cyclosporine can also raise tacrolimus levels, and the two should not be given together.
معنای این تداخل به زبان ساده
Cyclosporin and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclosporin belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
چرا رخ می‌دهد
Additive calcineurin inhibition and toxicity, with competition for CYP3A4 and P-glycoprotein altering exposure of either drug.
اقدام لازم
Do not combine the two. When switching, stop one and wait at least 24 hours before starting the other, guided by drug levels and renal function.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cyclosporin و Tacrolimus، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin منع مصرف
- Aliskiren + Cyclosporin منع مصرف
- Bcg vaccine live + Cyclosporin منع مصرف
- Bosentan + Cyclosporin منع مصرف
- Cidofovir + Cyclosporin منع مصرف
- Cyclosporin + Dengue vaccine منع مصرف
تداخلات دیگر Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus منع مصرف
- Bcg vaccine live + Tacrolimus منع مصرف
- Cidofovir + Tacrolimus منع مصرف
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus منع مصرف
- Measles mumps and rubella vaccine live + Tacrolimus منع مصرف
- Measles mumps and rubella vaccine + Tacrolimus منع مصرف
پرسش‌های متداول
Can I take Cyclosporin with Tacrolimus?
MediHelp rates the interaction as contraindicated. Cyclosporin and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are calcineurin inhibitors and together they increase nephrotoxicity, neurotoxicity and over-immunosuppression. Cyclosporine can also raise tacrolimus levels, and the two should not be given together.
How serious is the interaction between Cyclosporin and Tacrolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine the two. When switching, stop one and wait at least 24 hours before starting the other, guided by drug levels and renal function.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
