تداخل‌های دارویی
Cyclosporin + Topotecan
شدت: شدید
Cyclosporin and Topotecan: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cyclosporine raises topotecan exposure, particularly with oral topotecan, which may intensify myelosuppression and gastrointestinal toxicity. Both transporters involved in topotecan efflux are inhibited by cyclosporine.
معنای این تداخل به زبان ساده
Cyclosporin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Topotecan belongs to Oncology.
چرا رخ می‌دهد
Cyclosporine inhibits P-glycoprotein and BCRP efflux of topotecan, increasing its absorption and reducing clearance.
اقدام لازم
Avoid concomitant use, especially with oral topotecan; if unavoidable, monitor blood counts frequently and consider dose reduction.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cyclosporin و Topotecan، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin منع مصرف
- Aliskiren + Cyclosporin منع مصرف
- Bcg vaccine live + Cyclosporin منع مصرف
- Bosentan + Cyclosporin منع مصرف
- Cidofovir + Cyclosporin منع مصرف
- Cyclosporin + Dengue vaccine منع مصرف
تداخلات دیگر Topotecan
پرسش‌های متداول
Can I take Cyclosporin with Topotecan?
MediHelp rates the interaction as major. Cyclosporin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine raises topotecan exposure, particularly with oral topotecan, which may intensify myelosuppression and gastrointestinal toxicity. Both transporters involved in topotecan efflux are inhibited by cyclosporine.
How serious is the interaction between Cyclosporin and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use, especially with oral topotecan; if unavoidable, monitor blood counts frequently and consider dose reduction.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
