تداخل‌های دارویی
Deferiprone + Pyrimethamine
شدت: شدید
Deferiprone and Pyrimethamine: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Deferiprone can cause neutropenia and agranulocytosis, and pyrimethamine, as a folate antagonist, can cause bone marrow suppression. Combined use may increase the risk of severe hematologic toxicity.
معنای این تداخل به زبان ساده
Deferiprone and Pyrimethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Pyrimethamine belongs to Anti Parasitic.
چرا رخ می‌دهد
Additive myelosuppression (pharmacodynamic); pyrimethamine inhibits dihydrofolate reductase.
اقدام لازم
Avoid the combination if an alternative exists. If it is necessary, monitor absolute neutrophil count and platelets more frequently, and interrupt deferiprone for neutropenia.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Deferiprone و Pyrimethamine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Pyrimethamine
تداخلات دیگر Deferiprone
پرسش‌های متداول
Can I take Deferiprone with Pyrimethamine?
MediHelp rates the interaction as major. Deferiprone and Pyrimethamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferiprone can cause neutropenia and agranulocytosis, and pyrimethamine, as a folate antagonist, can cause bone marrow suppression. Combined use may increase the risk of severe hematologic toxicity.
How serious is the interaction between Deferiprone and Pyrimethamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is necessary, monitor absolute neutrophil count and platelets more frequently, and interrupt deferiprone for neutropenia.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Eliglustat, Acalabrutinib, Brexpiprazole. The full list is on the Pyrimethamine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
