رفتن به محتوا

تداخل‌های دارویی

Diclofenac + Pemetrexed

شدت: شدید

Diclofenac and Pemetrexed: major interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

NSAIDs can reduce the renal clearance of pemetrexed, leading to higher exposure and increased myelosuppression, renal and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment.

معنای این تداخل به زبان ساده

Diclofenac and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Diclofenac belongs to Musculoskeletal; Pemetrexed belongs to Oncology.

سطح شواهد: Moderate

چرا رخ می‌دهد

Reduced renal elimination of pemetrexed, likely through NSAID effects on renal perfusion and tubular handling.

اقدام لازم

Avoid diclofenac around pemetrexed dosing, following labeling guidance on NSAID interruption. If it must be used, monitor blood counts and renal function closely.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Diclofenac و Pemetrexed، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Diclofenac with Pemetrexed?

MediHelp rates the interaction as major. Diclofenac and Pemetrexed can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs can reduce the renal clearance of pemetrexed, leading to higher exposure and increased myelosuppression, renal and gastrointestinal toxicity. The risk is greatest in patients with mild to moderate renal impairment.

How serious is the interaction between Diclofenac and Pemetrexed?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid diclofenac around pemetrexed dosing, following labeling guidance on NSAID interruption. If it must be used, monitor blood counts and renal function closely.

What other medicines interact with Diclofenac?

MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.

تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp

مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.

مرور از A تا Z · تداخل‌های دارویی

دریافت برنامه ورود