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تداخل‌های دارویی

Disopyramide + Maprotiline

شدت: منع مصرف

Disopyramide and Maprotiline: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Both drugs can prolong the QT interval, and combining them raises the risk of torsades de pointes and other serious ventricular arrhythmias. Maprotiline also has quinidine-like conduction effects, and disopyramide is itself strongly proarrhythmic.

معنای این تداخل به زبان ساده

Disopyramide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Disopyramide belongs to Cardiovascular; Maprotiline belongs to Central Nervous System.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive pharmacodynamic QT prolongation and slowed cardiac conduction.

اقدام لازم

Avoid the combination and choose an antidepressant with lower QT liability if an antiarrhythmic is required. If it cannot be avoided, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc continuously.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Disopyramide و Maprotiline، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Disopyramide with Maprotiline?

MediHelp rates the interaction as contraindicated. Disopyramide and Maprotiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and combining them raises the risk of torsades de pointes and other serious ventricular arrhythmias. Maprotiline also has quinidine-like conduction effects, and disopyramide is itself strongly proarrhythmic.

How serious is the interaction between Disopyramide and Maprotiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antidepressant with lower QT liability if an antiarrhythmic is required. If it cannot be avoided, obtain a baseline ECG, correct potassium and magnesium, and monitor QTc continuously.

What other medicines interact with Maprotiline?

MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Maprotiline page.

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