تداخلهای دارویی
Doxycycline + Methoxyflurane
شدت: شدید
Doxycycline and Methoxyflurane: major interaction.
آخرین بهروزرسانی
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خلاصه
Methoxyflurane is nephrotoxic through fluoride release, and tetracyclines have been linked to fatal renal toxicity when used with it. Doxycycline is less renally harmful than other tetracyclines, but the labeling advises against the combination.
معنای این تداخل به زبان ساده
Doxycycline and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ میدهد
Additive nephrotoxicity; tetracycline antianabolic effects and methoxyflurane fluoride-induced tubular injury.
اقدام لازم
Avoid methoxyflurane in patients taking tetracyclines, including doxycycline, where alternatives exist. If unavoidable, use the lowest dose and monitor renal function.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Doxycycline و Methoxyflurane، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Doxycycline
پرسشهای متداول
Can I take Doxycycline with Methoxyflurane?
MediHelp rates the interaction as major. Doxycycline and Methoxyflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methoxyflurane is nephrotoxic through fluoride release, and tetracyclines have been linked to fatal renal toxicity when used with it. Doxycycline is less renally harmful than other tetracyclines, but the labeling advises against the combination.
How serious is the interaction between Doxycycline and Methoxyflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid methoxyflurane in patients taking tetracyclines, including doxycycline, where alternatives exist. If unavoidable, use the lowest dose and monitor renal function.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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