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Dronedarone + Nirmatrelvir

شدت: منع مصرف

Dronedarone and Nirmatrelvir: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Nirmatrelvir is a CYP3A4 inhibitor and is given with ritonavir, which further boosts inhibition. Dronedarone levels can rise substantially, increasing the risk of proarrhythmia and QT prolongation.

معنای این تداخل به زبان ساده

Dronedarone and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dronedarone belongs to Cardiovascular; Nirmatrelvir belongs to Anti Virals.

سطح شواهد: Moderate

چرا رخ می‌دهد

Inhibition of CYP3A4 reduces dronedarone clearance.

اقدام لازم

Avoid the combination; consider withholding dronedarone during antiviral treatment only under specialist guidance, or use an alternative COVID-19 therapy.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Dronedarone و Nirmatrelvir، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Dronedarone with Nirmatrelvir?

MediHelp rates the interaction as contraindicated. Dronedarone and Nirmatrelvir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nirmatrelvir is a CYP3A4 inhibitor and is given with ritonavir, which further boosts inhibition. Dronedarone levels can rise substantially, increasing the risk of proarrhythmia and QT prolongation.

How serious is the interaction between Dronedarone and Nirmatrelvir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; consider withholding dronedarone during antiviral treatment only under specialist guidance, or use an alternative COVID-19 therapy.

What other medicines interact with Dronedarone?

MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.

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