تداخل‌های دارویی
Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol
شدت: منع مصرف
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-salmeterol: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Cobicistat is a strong CYP3A4 inhibitor that increases salmeterol exposure, with risk of QT prolongation and arrhythmia. It also raises systemic fluticasone levels, so Cushing's syndrome and adrenal suppression can occur with prolonged use.
معنای این تداخل به زبان ساده
Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-salmeterol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
چرا رخ می‌دهد
Strong CYP3A4 inhibition by cobicistat reduces clearance of salmeterol and fluticasone.
اقدام لازم
Avoid the combination and consider an alternative such as beclomethasone with a non-CYP3A4-dependent LABA. If it cannot be avoided, monitor ECG, potassium and adrenal function.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Elvitegravir / cobicistat / emtricitabine / tenofovir df و Fluticasone-salmeterol، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol منع مصرف
- Fluticasone-salmeterol + Fosamprenavir منع مصرف
- Fluticasone-salmeterol + Indinavir منع مصرف
- Fluticasone-salmeterol + Lopinavir منع مصرف
- Fluticasone-salmeterol + Nelfinavir منع مصرف
- Fluticasone-salmeterol + Ritonavir منع مصرف
پرسش‌های متداول
Can I take Elvitegravir / cobicistat / emtricitabine / tenofovir df with Fluticasone-salmeterol?
MediHelp rates the interaction as contraindicated. Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-salmeterol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A4 inhibitor that increases salmeterol exposure, with risk of QT prolongation and arrhythmia. It also raises systemic fluticasone levels, so Cushing's syndrome and adrenal suppression can occur with prolonged use.
How serious is the interaction between Elvitegravir / cobicistat / emtricitabine / tenofovir df and Fluticasone-salmeterol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider an alternative such as beclomethasone with a non-CYP3A4-dependent LABA. If it cannot be avoided, monitor ECG, potassium and adrenal function.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Fosamprenavir, Indinavir. The full list is on the Fluticasone-salmeterol page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
