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Enalapril-hydrochlorothiazide + Protein a column

شدت: منع مصرف

Enalapril-hydrochlorothiazide and Protein a column: contraindicated interaction.

آخرین به‌روزرسانی

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خلاصه

Patients on ACE inhibitors undergoing apheresis with a protein A immunoadsorption column have developed anaphylactoid reactions. Bradykinin accumulates because ACE inhibition blocks its breakdown, and column treatment can further activate bradykinin-related pathways.

معنای این تداخل به زبان ساده

Enalapril-hydrochlorothiazide and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

سطح شواهد: Moderate

چرا رخ می‌دهد

ACE inhibitors block kininase II degradation of bradykinin, which accumulates during immunoadsorption and triggers anaphylactoid reactions.

اقدام لازم

Stop the ACE inhibitor well before the procedure (labeling advises about 72 hours) and use a non-ACE-inhibitor antihypertensive meanwhile.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Enalapril-hydrochlorothiazide و Protein a column، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Enalapril-hydrochlorothiazide with Protein a column?

MediHelp rates the interaction as contraindicated. Enalapril-hydrochlorothiazide and Protein a column are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Patients on ACE inhibitors undergoing apheresis with a protein A immunoadsorption column have developed anaphylactoid reactions. Bradykinin accumulates because ACE inhibition blocks its breakdown, and column treatment can further activate bradykinin-related pathways.

How serious is the interaction between Enalapril-hydrochlorothiazide and Protein a column?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop the ACE inhibitor well before the procedure (labeling advises about 72 hours) and use a non-ACE-inhibitor antihypertensive meanwhile.

What other medicines interact with Enalapril-hydrochlorothiazide?

MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Enalapril-hydrochlorothiazide page.

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