تداخل‌های دارویی
Ertapenem + Valproic acid
شدت: منع مصرف
Ertapenem and Valproic acid: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Ertapenem markedly lowers serum valproic acid concentrations, which can fall below the therapeutic range within a day or two. This can cause loss of seizure control, and the reduction may persist after the antibiotic is discontinued.
معنای این تداخل به زبان ساده
Ertapenem and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ertapenem belongs to Anti Bacterial; Valproic acid belongs to Central Nervous System.
چرا رخ می‌دهد
Carbapenems are thought to inhibit hydrolysis of valproate glucuronide back to valproate and may reduce its absorption and red cell uptake, lowering valproate concentrations.
اقدام لازم
Avoid the combination and choose a non-carbapenem antibiotic. If unavoidable, add a different anticonvulsant and monitor valproate levels and seizure activity, including after the antibiotic ends.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Ertapenem و Valproic acid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Ertapenem
تداخلات دیگر Valproic acid
پرسش‌های متداول
Can I take Ertapenem with Valproic acid?
MediHelp rates the interaction as contraindicated. Ertapenem and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ertapenem markedly lowers serum valproic acid concentrations, which can fall below the therapeutic range within a day or two. This can cause loss of seizure control, and the reduction may persist after the antibiotic is discontinued.
How serious is the interaction between Ertapenem and Valproic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-carbapenem antibiotic. If unavoidable, add a different anticonvulsant and monitor valproate levels and seizure activity, including after the antibiotic ends.
What other medicines interact with Ertapenem?
MediHelp also lists interactions of Ertapenem with, for example, Typhoid vaccine live, Cholera vaccine, Microbiota. The full list is on the Ertapenem page.
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