Ethanol + Insulin aspart

MediHelp rates the interaction as major. Ethanol and Insulin aspart can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Alcohol can cause unpredictable glycemic effects in insulin-treated patients. It suppresses hepatic gluconeogenesis, which can produce serious and delayed hypoglycemia, particularly when drinking occurs without food, while sugary drinks can raise glucose. Hypoglycemia symptoms may also be mistaken for intoxication.

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to drink only in moderation and with food, and to monitor blood glucose more often, including overnight and the next morning. Ensure companions know how to recognize and treat hypoglycemia.

MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Glimepiride-pioglitazone, Metformin-pioglitazone. The full list is on the Insulin aspart page.