تداخل‌های دارویی
Fluoxetine + Rasagiline
شدت: منع مصرف
Fluoxetine and Rasagiline: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Combining an SSRI with a monoamine oxidase B inhibitor can cause serotonin syndrome, with severe hyperthermia, rigidity and autonomic instability reported with antidepressants and rasagiline. Fluoxetine's very long-acting metabolite prolongs the risk after it is stopped.
معنای این تداخل به زبان ساده
Fluoxetine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fluoxetine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
چرا رخ می‌دهد
Reduced serotonin breakdown from MAO inhibition combined with serotonin reuptake inhibition produces excess serotonergic activity.
اقدام لازم
Do not co-administer; rasagiline labeling advises waiting about five weeks after stopping fluoxetine before starting rasagiline, and at least 14 days after stopping rasagiline before starting fluoxetine. Treat suspected serotonin syndrome by stopping both drugs and giving supportive care.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Fluoxetine و Rasagiline، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Fluoxetine
- Fluoxetine + Isocarboxazid منع مصرف
- Fluoxetine + Mavacamten منع مصرف
- Fluoxetine + Methylene blue منع مصرف
- Fluoxetine + Phenelzine منع مصرف
- Fluoxetine + Pimozide منع مصرف
- Fluoxetine + Selegiline منع مصرف
تداخلات دیگر Rasagiline
- Atomoxetine + Rasagiline منع مصرف
- Brimonidine + Rasagiline منع مصرف
- Bupropion-naltrexone + Rasagiline منع مصرف
- Bupropion + Rasagiline منع مصرف
- Clomipramine + Rasagiline منع مصرف
- Desvenlafaxine + Rasagiline منع مصرف
پرسش‌های متداول
Can I take Fluoxetine with Rasagiline?
MediHelp rates the interaction as contraindicated. Fluoxetine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an SSRI with a monoamine oxidase B inhibitor can cause serotonin syndrome, with severe hyperthermia, rigidity and autonomic instability reported with antidepressants and rasagiline. Fluoxetine's very long-acting metabolite prolongs the risk after it is stopped.
How serious is the interaction between Fluoxetine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; rasagiline labeling advises waiting about five weeks after stopping fluoxetine before starting rasagiline, and at least 14 days after stopping rasagiline before starting fluoxetine. Treat suspected serotonin syndrome by stopping both drugs and giving supportive care.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
