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تداخل‌های دارویی

Fostemsavir + Pimozide

شدت: شدید

Fostemsavir and Pimozide: major interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Fostemsavir has caused QT prolongation at supratherapeutic doses, and pimozide is a strongly QT-prolonging drug with a narrow margin of safety. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.

معنای این تداخل به زبان ساده

Fostemsavir and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Fostemsavir belongs to Anti Virals; Pimozide belongs to Central Nervous System.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive QT-interval prolongation through cardiac repolarization effects.

اقدام لازم

Obtain a baseline ECG and monitor QTc and electrolytes if the combination cannot be avoided. Correct potassium and magnesium abnormalities, and choose an alternative if QTc becomes markedly prolonged.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Fostemsavir و Pimozide، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Fostemsavir with Pimozide?

MediHelp rates the interaction as major. Fostemsavir and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fostemsavir has caused QT prolongation at supratherapeutic doses, and pimozide is a strongly QT-prolonging drug with a narrow margin of safety. Combined use may increase the risk of torsades de pointes, particularly with other risk factors.

How serious is the interaction between Fostemsavir and Pimozide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes if the combination cannot be avoided. Correct potassium and magnesium abnormalities, and choose an alternative if QTc becomes markedly prolonged.

What other medicines interact with Pimozide?

MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.

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