تداخل‌های دارویی
Glimepiride-pioglitazone + Sulfamethoxazole
شدت: شدید
Glimepiride-pioglitazone and Sulfamethoxazole: major interaction.
آخرین به‌روزرسانی
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خلاصه
Sulfamethoxazole, usually given with trimethoprim, can enhance the hypoglycemic effect of glimepiride. Severe hypoglycemia has been reported with sulfonylurea and co-trimoxazole combinations, especially in older patients or those with renal impairment.
معنای این تداخل به زبان ساده
Glimepiride-pioglitazone and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Sulfamethoxazole inhibits CYP2C9 metabolism of sulfonylureas and may displace them from protein binding, increasing glimepiride exposure.
اقدام لازم
Monitor blood glucose frequently during co-trimoxazole therapy and reduce the glimepiride dose if needed. Consider an alternative antibiotic in high-risk patients.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Glimepiride-pioglitazone و Sulfamethoxazole، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Glimepiride-pioglitazone
پرسش‌های متداول
Can I take Glimepiride-pioglitazone with Sulfamethoxazole?
MediHelp rates the interaction as major. Glimepiride-pioglitazone and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sulfamethoxazole, usually given with trimethoprim, can enhance the hypoglycemic effect of glimepiride. Severe hypoglycemia has been reported with sulfonylurea and co-trimoxazole combinations, especially in older patients or those with renal impairment.
How serious is the interaction between Glimepiride-pioglitazone and Sulfamethoxazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during co-trimoxazole therapy and reduce the glimepiride dose if needed. Consider an alternative antibiotic in high-risk patients.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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