تداخل‌های دارویی
Glyburide + Miconazole
شدت: شدید
Glyburide and Miconazole: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Glyburide is metabolized by CYP2C9 and CYP3A4, both inhibited by miconazole. Increased levels can cause severe and prolonged hypoglycemia, and cases have been reported with miconazole. The risk is greater in elderly patients and those with renal impairment.
معنای این تداخل به زبان ساده
Glyburide and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glyburide belongs to Endocrine; Miconazole belongs to Anti Fungals.
چرا رخ می‌دهد
Miconazole inhibits CYP2C9 and CYP3A4, reducing glyburide clearance.
اقدام لازم
Monitor blood glucose frequently and counsel on hypoglycemia symptoms. Reduce the glyburide dose or switch to a non-azole antifungal or alternative agent if feasible.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Glyburide و Miconazole، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Miconazole
تداخلات دیگر Glyburide
پرسش‌های متداول
Can I take Glyburide with Miconazole?
MediHelp rates the interaction as major. Glyburide and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glyburide is metabolized by CYP2C9 and CYP3A4, both inhibited by miconazole. Increased levels can cause severe and prolonged hypoglycemia, and cases have been reported with miconazole. The risk is greater in elderly patients and those with renal impairment.
How serious is the interaction between Glyburide and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and counsel on hypoglycemia symptoms. Reduce the glyburide dose or switch to a non-azole antifungal or alternative agent if feasible.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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