تداخل‌های دارویی
Imipramine + Rasagiline
شدت: منع مصرف
Imipramine and Rasagiline: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Combining a tricyclic antidepressant with an MAO-B inhibitor has been associated with serious reactions including serotonin syndrome, hyperpyrexia and severe CNS toxicity. Labeling advises against concurrent use and separating the drugs by a washout period.
معنای این تداخل به زبان ساده
Imipramine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Imipramine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
چرا رخ می‌دهد
MAO inhibition combined with tricyclic reuptake blockade increases synaptic monoamines, causing serotonergic and adrenergic toxicity.
اقدام لازم
Do not co-administer; allow at least 14 days after stopping rasagiline before starting imipramine, and an adequate tricyclic washout before rasagiline.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Imipramine و Rasagiline، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Imipramine
- Dronedarone + Imipramine منع مصرف
- Imipramine + Isocarboxazid منع مصرف
- Imipramine + Phenelzine منع مصرف
- Imipramine + Pimozide منع مصرف
- Imipramine + Safinamide منع مصرف
- Imipramine + Selegiline منع مصرف
تداخلات دیگر Rasagiline
- Atomoxetine + Rasagiline منع مصرف
- Brimonidine + Rasagiline منع مصرف
- Bupropion-naltrexone + Rasagiline منع مصرف
- Bupropion + Rasagiline منع مصرف
- Clomipramine + Rasagiline منع مصرف
- Desvenlafaxine + Rasagiline منع مصرف
پرسش‌های متداول
Can I take Imipramine with Rasagiline?
MediHelp rates the interaction as contraindicated. Imipramine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining a tricyclic antidepressant with an MAO-B inhibitor has been associated with serious reactions including serotonin syndrome, hyperpyrexia and severe CNS toxicity. Labeling advises against concurrent use and separating the drugs by a washout period.
How serious is the interaction between Imipramine and Rasagiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; allow at least 14 days after stopping rasagiline before starting imipramine, and an adequate tricyclic washout before rasagiline.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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