تداخل‌های دارویی
Ledipasvir-sofosbuvir + St john's wort
شدت: منع مصرف
Ledipasvir-sofosbuvir and St john's wort: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
St John's wort is a potent inducer of intestinal P-glycoprotein and can markedly lower plasma concentrations of both ledipasvir and sofosbuvir. Reduced exposure may lead to loss of antiviral activity, failure to achieve sustained virologic response and possible resistance.
معنای این تداخل به زبان ساده
Ledipasvir-sofosbuvir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
چرا رخ می‌دهد
Induction of intestinal P-glycoprotein (and other inducible pathways) by St John's wort reduces absorption and plasma exposure of ledipasvir and sofosbuvir.
اقدام لازم
Do not combine; stop St John's wort before starting the hepatitis C regimen and choose an alternative if a herbal antidepressant is desired. Counsel patients to avoid herbal products during treatment.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Ledipasvir-sofosbuvir و St john's wort، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir منع مصرف
- Ledipasvir-sofosbuvir + Phenobarbital منع مصرف
- Ledipasvir-sofosbuvir + Phenytoin منع مصرف
- Ledipasvir-sofosbuvir + Rifampin منع مصرف
- Ledipasvir-sofosbuvir + Rifapentine منع مصرف
- Ledipasvir-sofosbuvir + Tipranavir منع مصرف
پرسش‌های متداول
Can I take Ledipasvir-sofosbuvir with St john's wort?
MediHelp rates the interaction as contraindicated. Ledipasvir-sofosbuvir and St john's wort are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. St John's wort is a potent inducer of intestinal P-glycoprotein and can markedly lower plasma concentrations of both ledipasvir and sofosbuvir. Reduced exposure may lead to loss of antiviral activity, failure to achieve sustained virologic response and possible resistance.
How serious is the interaction between Ledipasvir-sofosbuvir and St john's wort?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; stop St John's wort before starting the hepatitis C regimen and choose an alternative if a herbal antidepressant is desired. Counsel patients to avoid herbal products during treatment.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
