تداخل‌های دارویی
Lorlatinib + Primidone
شدت: منع مصرف
Lorlatinib and Primidone: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Primidone is metabolized to phenobarbital and acts as a strong CYP3A4 inducer, which can lower lorlatinib concentrations and risk treatment failure. Strong inducers are contraindicated with lorlatinib, and hepatotoxicity has been seen with this type of combination.
معنای این تداخل به زبان ساده
Lorlatinib and Primidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lorlatinib belongs to Oncology; Primidone belongs to Central Nervous System.
چرا رخ می‌دهد
Induction of CYP3A4 by primidone and its phenobarbital metabolite accelerates lorlatinib metabolism.
اقدام لازم
Do not co-administer; switch to a non-inducing anticonvulsant. Allow washout of about 3 half-lives of the inducer before starting lorlatinib.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Lorlatinib و Primidone، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Lorlatinib
- Amobarbital + Lorlatinib منع مصرف
- Apalutamide + Lorlatinib منع مصرف
- Butabarbital + Lorlatinib منع مصرف
- Carbamazepine + Lorlatinib منع مصرف
- Enzalutamide + Lorlatinib منع مصرف
- Fosphenytoin + Lorlatinib منع مصرف
تداخلات دیگر Primidone
- Lurasidone + Primidone منع مصرف
- Primidone + Ranolazine منع مصرف
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir منع مصرف
- Primidone + Voriconazole منع مصرف
- Abiraterone + Primidone شدید
- Amitriptyline + Primidone شدید
پرسش‌های متداول
Can I take Lorlatinib with Primidone?
MediHelp rates the interaction as contraindicated. Lorlatinib and Primidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Primidone is metabolized to phenobarbital and acts as a strong CYP3A4 inducer, which can lower lorlatinib concentrations and risk treatment failure. Strong inducers are contraindicated with lorlatinib, and hepatotoxicity has been seen with this type of combination.
How serious is the interaction between Lorlatinib and Primidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; switch to a non-inducing anticonvulsant. Allow washout of about 3 half-lives of the inducer before starting lorlatinib.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
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