تداخل‌های دارویی
Metoclopramide + Rivastigmine
شدت: شدید
Metoclopramide and Rivastigmine: major interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Rivastigmine, a cholinesterase inhibitor, may increase the risk of extrapyramidal symptoms when given with metoclopramide. Cholinesterase inhibitors can also worsen parkinsonism, and metoclopramide's dopamine blockade adds to this. Neuroleptic malignant syndrome is a rare concern.
معنای این تداخل به زبان ساده
Metoclopramide and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metoclopramide belongs to Gastrointestinal Tract; Rivastigmine belongs to Central Nervous System.
چرا رخ می‌دهد
Metoclopramide blocks central D2 receptors while rivastigmine increases cholinergic tone, and the two together promote extrapyramidal effects; cholinergic effects on gut motility may also be additive.
اقدام لازم
Avoid the combination where possible, especially in patients with Parkinson disease or dementia. If needed, use the lowest metoclopramide dose briefly and monitor for tremor, rigidity and dystonia.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Metoclopramide و Rivastigmine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Metoclopramide
تداخلات دیگر Rivastigmine
پرسش‌های متداول
Can I take Metoclopramide with Rivastigmine?
MediHelp rates the interaction as major. Metoclopramide and Rivastigmine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rivastigmine, a cholinesterase inhibitor, may increase the risk of extrapyramidal symptoms when given with metoclopramide. Cholinesterase inhibitors can also worsen parkinsonism, and metoclopramide's dopamine blockade adds to this. Neuroleptic malignant syndrome is a rare concern.
How serious is the interaction between Metoclopramide and Rivastigmine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially in patients with Parkinson disease or dementia. If needed, use the lowest metoclopramide dose briefly and monitor for tremor, rigidity and dystonia.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
