تداخل‌های دارویی
Mitoxantrone + Trastuzumab
شدت: شدید
Mitoxantrone and Trastuzumab: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Trastuzumab combined with an anthracenedione such as mitoxantrone increases the risk of heart failure and reduced left ventricular ejection fraction. Neutropenia may also be more frequent when trastuzumab is added to myelosuppressive chemotherapy.
معنای این تداخل به زبان ساده
Mitoxantrone and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mitoxantrone belongs to Central Nervous System; Trastuzumab belongs to Oncology.
چرا رخ می‌دهد
Additive cardiotoxicity from HER2 inhibition of cardiomyocyte survival signalling combined with mitoxantrone's direct myocardial damage; additive myelosuppression also contributes.
اقدام لازم
Avoid concurrent use where possible. Assess LVEF before and periodically during therapy and monitor neutrophil counts.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Mitoxantrone و Trastuzumab، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Mitoxantrone
تداخلات دیگر Trastuzumab
پرسش‌های متداول
Can I take Mitoxantrone with Trastuzumab?
MediHelp rates the interaction as major. Mitoxantrone and Trastuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trastuzumab combined with an anthracenedione such as mitoxantrone increases the risk of heart failure and reduced left ventricular ejection fraction. Neutropenia may also be more frequent when trastuzumab is added to myelosuppressive chemotherapy.
How serious is the interaction between Mitoxantrone and Trastuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible. Assess LVEF before and periodically during therapy and monitor neutrophil counts.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
