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Mycophenolic acid + Valacyclovir

شدت: متوسط

Mycophenolic acid and Valacyclovir: moderate interaction.

آخرین به‌روزرسانی

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خلاصه

Valacyclovir is converted to acyclovir, which competes with mycophenolate glucuronide for renal tubular secretion. Both may accumulate, particularly with reduced kidney function, raising the risk of neutropenia or neurotoxicity.

معنای این تداخل به زبان ساده

Mycophenolic acid and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Mycophenolic acid belongs to Miscellaneous; Valacyclovir belongs to Anti Virals.

سطح شواهد: Moderate

چرا رخ می‌دهد

Competition between acyclovir and MPA glucuronide for renal tubular secretion.

اقدام لازم

Monitor complete blood counts and renal function. Reduce doses if cytopenias or renal impairment occur.

از داروساز چه بپرسید

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Mycophenolic acid و Valacyclovir، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Mycophenolic acid with Valacyclovir?

MediHelp rates the interaction as moderate. Mycophenolic acid and Valacyclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valacyclovir is converted to acyclovir, which competes with mycophenolate glucuronide for renal tubular secretion. Both may accumulate, particularly with reduced kidney function, raising the risk of neutropenia or neurotoxicity.

How serious is the interaction between Mycophenolic acid and Valacyclovir?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and renal function. Reduce doses if cytopenias or renal impairment occur.

What other medicines interact with Mycophenolic acid?

MediHelp also lists interactions of Mycophenolic acid with, for example, Activated charcoal, Azathioprine, Cholestyramine. The full list is on the Mycophenolic acid page.

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