تداخل‌های دارویی
Oxcarbazepine + Rilpivirine
شدت: منع مصرف
Oxcarbazepine and Rilpivirine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Oxcarbazepine can lower rilpivirine plasma concentrations through induction of CYP3A4. Reduced exposure may lead to loss of virologic suppression and development of resistance to rilpivirine and the NNRTI class.
معنای این تداخل به زبان ساده
Oxcarbazepine and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Oxcarbazepine belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
چرا رخ می‌دهد
Oxcarbazepine induces CYP3A4, increasing the metabolism of rilpivirine, a CYP3A4 substrate.
اقدام لازم
Avoid the combination, as rilpivirine labeling contraindicates enzyme-inducing anticonvulsants of this type. Use an alternative antiseizure drug with no inducing effect, or an alternative antiretroviral regimen.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Oxcarbazepine و Rilpivirine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Oxcarbazepine
تداخلات دیگر Rilpivirine
- Carbamazepine + Rilpivirine منع مصرف
- Dexamethasone + Rilpivirine منع مصرف
- Dexlansoprazole + Rilpivirine منع مصرف
- Efavirenz + Rilpivirine منع مصرف
- Eslicarbazepine + Rilpivirine منع مصرف
- Esomeprazole + Rilpivirine منع مصرف
پرسش‌های متداول
Can I take Oxcarbazepine with Rilpivirine?
MediHelp rates the interaction as contraindicated. Oxcarbazepine and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oxcarbazepine can lower rilpivirine plasma concentrations through induction of CYP3A4. Reduced exposure may lead to loss of virologic suppression and development of resistance to rilpivirine and the NNRTI class.
How serious is the interaction between Oxcarbazepine and Rilpivirine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, as rilpivirine labeling contraindicates enzyme-inducing anticonvulsants of this type. Use an alternative antiseizure drug with no inducing effect, or an alternative antiretroviral regimen.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Artemether / lumefantrine, Atazanavir. The full list is on the Oxcarbazepine page.
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