Penicillin g procaine-penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid

MediHelp rates the interaction as moderate. Penicillin g procaine-penicillin g and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that needs colonic bacteria to convert it to its active laxative metabolite. Antibacterial agents that reduce colonic flora may lessen the bowel-cleansing effect, risking an inadequate preparation before colonoscopy. Parenteral penicillin G has less colonic exposure than oral antibiotics, so the effect is likely smaller.

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess bowel preparation quality and consider a supplemental or alternative cleansing regimen if the preparation appears inadequate. Where possible, avoid starting antibiotics shortly before or during the preparation.

MediHelp also lists interactions of Penicillin g procaine-penicillin g with, for example, Amifampridine, Baricitinib, Cholera vaccine. The full list is on the Penicillin g procaine-penicillin g page.