تداخلهای دارویی
Pexidartinib + Sulphasalazine
شدت: شدید
Pexidartinib and Sulphasalazine: major interaction.
آخرین بهروزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصهای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمیشود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and sulfasalazine can also cause hepatotoxicity. Using both increases the chance of liver injury.
معنای این تداخل به زبان ساده
Pexidartinib and Sulphasalazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Sulphasalazine belongs to Gastrointestinal Tract.
چرا رخ میدهد
Additive hepatotoxicity from two agents that can each cause liver injury.
اقدام لازم
Avoid the combination if possible. If both are needed, check liver tests at baseline and frequently, and stop treatment if liver injury develops.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Pexidartinib و Sulphasalazine، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Sulphasalazine
تداخلات دیگر Pexidartinib
پرسشهای متداول
Can I take Pexidartinib with Sulphasalazine?
MediHelp rates the interaction as major. Pexidartinib and Sulphasalazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and sulfasalazine can also cause hepatotoxicity. Using both increases the chance of liver injury.
How serious is the interaction between Pexidartinib and Sulphasalazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If both are needed, check liver tests at baseline and frequently, and stop treatment if liver injury develops.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Sepiapterin, Acalabrutinib. The full list is on the Sulphasalazine page.
تکنگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.