تداخل‌های دارویی
Piperacillin + Vancomycin
شدت: شدید
Piperacillin and Vancomycin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Piperacillin-tazobactam combined with vancomycin is associated with a higher incidence of acute kidney injury than either vancomycin with other beta-lactams or alone. The injury is often reversible but can prolong hospitalization and complicate dosing.
معنای این تداخل به زبان ساده
Piperacillin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Piperacillin belongs to Anti Bacterial; Vancomycin belongs to Anti Bacterial.
چرا رخ می‌دهد
Mechanism is not fully established; possible additive tubular injury and reduced tubular creatinine secretion may contribute.
اقدام لازم
Monitor serum creatinine and urine output closely, and use vancomycin trough or AUC-guided dosing. Consider an alternative beta-lactam if renal function declines and the clinical situation allows.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Piperacillin و Vancomycin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Piperacillin
تداخلات دیگر Vancomycin
پرسش‌های متداول
Can I take Piperacillin with Vancomycin?
MediHelp rates the interaction as major. Piperacillin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Piperacillin-tazobactam combined with vancomycin is associated with a higher incidence of acute kidney injury than either vancomycin with other beta-lactams or alone. The injury is often reversible but can prolong hospitalization and complicate dosing.
How serious is the interaction between Piperacillin and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output closely, and use vancomycin trough or AUC-guided dosing. Consider an alternative beta-lactam if renal function declines and the clinical situation allows.
What other medicines interact with Piperacillin?
MediHelp also lists interactions of Piperacillin with, for example, Acetylsalicylic acid, Amikacin, Antithrombin alfa. The full list is on the Piperacillin page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
