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تداخل‌های دارویی

Rabeprazole + Rilpivirine

شدت: منع مصرف

Rabeprazole and Rilpivirine: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Rabeprazole substantially lowers oral rilpivirine concentrations, which may cause virologic failure and NNRTI resistance. Labeling contraindicates the combination.

معنای این تداخل به زبان ساده

Rabeprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Rabeprazole belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.

سطح شواهد: High

چرا رخ می‌دهد

Elevated gastric pH reduces absorption of oral rilpivirine, which needs an acidic environment.

اقدام لازم

Do not coadminister; choose a different acid-reducing strategy or antiretroviral. If acid suppression is essential, H2 blockers need timed separation (rilpivirine at least 4 hours before or 12 hours after).

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Rabeprazole و Rilpivirine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Rabeprazole with Rilpivirine?

MediHelp rates the interaction as contraindicated. Rabeprazole and Rilpivirine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rabeprazole substantially lowers oral rilpivirine concentrations, which may cause virologic failure and NNRTI resistance. Labeling contraindicates the combination.

How serious is the interaction between Rabeprazole and Rilpivirine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose a different acid-reducing strategy or antiretroviral. If acid suppression is essential, H2 blockers need timed separation (rilpivirine at least 4 hours before or 12 hours after).

What other medicines interact with Rabeprazole?

MediHelp also lists interactions of Rabeprazole with, for example, Acalabrutinib, Atazanavir, Dacomitinib. The full list is on the Rabeprazole page.

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