Référentiel des médicaments
Cefoperazone
Cefoperazone is a medicine in the class anti bacterial. It is used for endometritis.
- Classe médicamenteuse: Anti Bacterial
- Indications: endometritis
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L'essentiel
- Classe médicamenteuse
- Anti Bacterial
- Formes courantes
- injection
- Dosages courants
- 1 g, 500 mg, 2 g
- Noms commerciaux
- 22
- Pays et marchés
- 2
Indications
Mécanisme d'action
Cefoperazone, a third-generation cephalosporin, interferes with cell wall synthesis by binding to the penicillin-binding proteins (PBPs), thus preventing cross-linking of nascent peptidoglycan. Cefoperazone is stable to penicillinases and has a high degree of stability to many beta-lactamases produced by gram-negative bacteria.
Posologie adulte habituelle (résumé de la notice)
1 to 2 g IV or IM every 12 hours. Therapy should be continued for 7, 14, 21, or 30 days, according to the type of infection
Grossesse et allaitement
- Grossesse
- Safe No clear harm in available data; cephalosporins as a class are considered safe in pregnancy. It can lower vitamin K-dependent clotting and cause a reaction with alcohol. Use when needed, with clotting checks if at risk.
- Allaitement
- Safe Low milk levels in small studies (often undetectable). LactMed: acceptable; watch the infant for loose stools or thrush.
Effets indésirables signalés
- Diarrhea
- Transient elevations of the BUN
- neutropenia
Précautions particulières
- cefoperazone should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.
- As with other antibacterial drugs, vitamin K deficiency resulting in coagulopathy has occurred in patients treated with cefoperazone.
- A false-positive reaction for glucose in the urine may occur with Benedict’s or Fehling’s solution.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
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- Renal and hepatic dose adjustments
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- IV preparation and dilution
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Questions fréquentes
What is Cefoperazone used for?
Cefoperazone is a medicine in the class anti bacterial. It is used for Endometritis, Peritonitis, Pyelonephritis, Respiratory tract infections, Skin infections.
What side effects have been reported with Cefoperazone?
Diarrhea, Transient elevations of the BUN, neutropenia.
Can Cefoperazone be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. No clear harm in available data; cephalosporins as a class are considered safe in pregnancy. It can lower vitamin K-dependent clotting and cause a reaction with alcohol. Use when needed, with clotting checks if at risk. Breastfeeding: Safe. Low milk levels in small studies (often undetectable). LactMed: acceptable; watch the infant for loose stools or thrush.
What does Cefoperazone interact with?
MediHelp does not list a checked interaction for Cefoperazone yet. Always tell your pharmacist about every medicine you take.
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