Référentiel des médicaments
Cefepime
Cefepime is a medicine in the class anti bacterial. It is used for febrile neutropenia.
- Classe médicamenteuse: Anti Bacterial
- Indications: febrile neutropenia
Dernière mise à jour Sources: US FDA label, CIMA AEMPS (Spain), AEMPS CIMA ficha tecnica (Spanish)
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Anti Bacterial
- Formes courantes
- injection
- Dosages courants
- 1 g, 2 g, 500 mg
- Interactions connues
- 22 (Modérée: 12 · Mineure: 10)
- Noms commerciaux
- 47
- Pays et marchés
- 4
Indications
Mécanisme d'action
Fourth-generation cephalosporin; has gram-negative coverage comparable to ceftazidime but better gram-positive coverage (comparable to ceftriaxone); is zwitterion and rapidly penetrates gram-negative cells; is best beta-lactam for IM administration; has poor capacity to cross blood-brain barrier and thus is not used for treatment of meningitis
Posologie adulte habituelle (résumé de la notice)
Pneumonia : 1-2 g IV q8-12hr for 7-10 days (if not caused by Pseudomonas) or for up to 21 days (if caused by Pseudomonas)
Grossesse et allaitement
- Grossesse
- Safe Cephalosporins are widely used in pregnancy, and available data show no increase in birth defects; animal studies showed no harm. Considered a safe choice for serious infections.
- Allaitement
- Safe Passes into milk in low amounts. Compatible with breastfeeding; watch the infant for loose stools, rash or thrush.
Effets indésirables signalés
- Diarrhea
- Rash
- Positive Coombs test result without hemolysis
- Elevated alanine aminotransferase
- Hypophosphatemia
Contre-indications
- Documented hypersensitivity to cefepime, penicillins, or other beta-lactam antibiotics
Précautions particulières
- If CrCl <60 mL/min, adjust dosage to compensate for slower renal elimination rate
- Caution warranted with history of previous immediate hypersensitivity reactions to cefepime, cephalosporins, penicillins, or other drugs
- Prescribing drug in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to patient
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (22)
- Amikacin + Cefepime Moderate
- Cefepime + Cholera vaccine Moderate
- Cefepime + Dexamethasone-tobramycin Moderate
- Cefepime + Gentamicin Moderate
- Cefepime + Kanamycin Moderate
- Cefepime + Microbiota Moderate
- Cefepime + Plazomicin Moderate
- Cefepime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Cefepime + Streptomycin Moderate
- Cefepime + Tobramycin Moderate
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- Renal and hepatic dose adjustments
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- Pharmacokinetics
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- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Cefepime used for?
Cefepime is a medicine in the class anti bacterial. It is used for Febrile neutropenia, Intra-abdominal infections, Pneumonia, Sepsis, Skin infections, Urinary tract infections.
What side effects have been reported with Cefepime?
Diarrhea, Rash, Positive Coombs test result without hemolysis, Elevated alanine aminotransferase, Hypophosphatemia.
Can Cefepime be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Cephalosporins are widely used in pregnancy, and available data show no increase in birth defects; animal studies showed no harm. Considered a safe choice for serious infections. Breastfeeding: Safe. Passes into milk in low amounts. Compatible with breastfeeding; watch the infant for loose stools, rash or thrush.
What does Cefepime interact with?
MediHelp lists 22 known interactions for Cefepime. Moderate: 12 · Minor: 10. The most serious include Amikacin, Cholera vaccine, Dexamethasone-tobramycin.
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