Référentiel des médicaments
Dexlansoprazole
Dexlansoprazole is a medicine in the class gastrointestinal tract. It is used for gerd.
- Classe médicamenteuse: Gastrointestinal Tract
- Indications: gerd
Dernière mise à jour
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Gastrointestinal Tract
- Formes courantes
- gélule
- Dosages courants
- 60 mg, 30 mg
- Interactions connues
- 116 (Contre-indiquée: 2 · Majeure: 18 · Modérée: 46 · Mineure: 50)
- Noms commerciaux
- 22
- Pays et marchés
- 4
Indications
Mécanisme d'action
R-enantiomer of lansoprazole; PPI; binds to H+/K+-exchanging ATPase (proton pump) in gastric parietal cells, resulting in blockage of acid secretion, Dual release formulation, Relative Potency: not available.
Posologie adulte habituelle (résumé de la notice)
General dosing: 30-60 mg orally every day for up to 8 weeks.
Mode de prise habituel
Proton pump inhibitors are usually taken by mouth once a day, often before a meal, for a course whose length depends on the reason for treatment.
Grossesse et allaitement
- Grossesse
- Safe No human studies, but data for lansoprazole, of which it is an enantiomer, show no harm in pregnancy. Acceptable when a PPI is needed; omeprazole has the most pregnancy data.
- Allaitement
- Safe No milk data. LactMed: as lansoprazole has been used safely in newborns, the amount in milk is unlikely to harm the infant. Acceptable.
Effets indésirables signalés
- Vomiting
- Diarrhea
- Nausea
- Abdominal pain
- URI
Contre-indications
- Hypersensitivity reactions, including anaphylaxis and acute interstitial nephritis reported
- PPIs are contraindicated with rilpivirine-containing products
Précautions particulières
- Proton pump inhibitors (PPIs) are possibly associated with increased incidence of Clostridium difficile-associated diarrhea (CDAD).
- PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist, particularly with prolonged (>1 yr), high-dose therapy.
- Daily long-term use (e.g., longer than 3 years) may lead to malabsorption or a deficiency of cyanocobalamin.
People taking proton pump inhibitors for a long time should have the need for treatment reviewed, because long-term use is linked to low magnesium, vitamin B12 deficiency, bone fractures and gut infections. Tell your pharmacist about all other medicines, since some interact.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (116)
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
- Dexlansoprazole + Erlotinib Major
- Dexlansoprazole + Gefitinib Major
- Dexlansoprazole + Infigratinib Major
- Dexlansoprazole + Itraconazole Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Dexlansoprazole used for?
Dexlansoprazole is a medicine in the class gastrointestinal tract. It is used for GERD, Peptic ulcer.
What side effects have been reported with Dexlansoprazole?
Vomiting, Diarrhea, Nausea, Abdominal pain, URI.
Can Dexlansoprazole be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. No human studies, but data for lansoprazole, of which it is an enantiomer, show no harm in pregnancy. Acceptable when a PPI is needed; omeprazole has the most pregnancy data. Breastfeeding: Safe. No milk data. LactMed: as lansoprazole has been used safely in newborns, the amount in milk is unlikely to harm the infant. Acceptable.
What does Dexlansoprazole interact with?
MediHelp lists 116 known interactions for Dexlansoprazole. Contraindicated: 2 · Major: 18 · Moderate: 46 · Minor: 50. The most serious include Mavacamten, Rilpivirine, Acalabrutinib.
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