Référentiel des médicaments
Diazoxide
Diazoxide is a medicine in the class miscellaneous. It is used for hypoglycemia.
- Classe médicamenteuse: Miscellaneous
- Indications: hypoglycemia
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Formes courantes
- suspension buvable
- Dosages courants
- 50 mg/ml
- Interactions connues
- 40 (Majeure: 10 · Modérée: 30)
- Noms commerciaux
- 1
- Pays et marchés
- 1
Indications
Mécanisme d'action
Produces a dose-related rise in blood glucose, mainly by inhibiting insulin release from the pancreas, with an additional extrapancreatic effect.
Posologie adulte habituelle (résumé de la notice)
Hypoglycemia due to hyperinsulinism (adults and children): starting 3 mg/kg/day orally, divided into 3 equal doses every 8 hours or 2 equal doses every 12 hours; titrate to a maximum of 8 mg/kg/day; refractory hypoglycemia may need higher doses
Grossesse et allaitement
- Grossesse
- Unsafe Case reports are too few to assess birth-defect risk. It crosses the placenta: use before delivery has caused high blood sugar, hair loss and excess body hair in newborns, and labels warn of jaundice and low platelets. Use only if the mother's benefit outweighs the risk.
- Allaitement
- Unknown Present in human milk; no data on infant effects or milk supply. US labels: weigh breastfeeding against the mother's need (older label: choose one). If used, monitor the infant's blood glucose, especially in the newborn period.
Effets indésirables signalés
- Sodium and fluid retention
- Hirsutism (lanugo type)
- Hyperglycemia or glycosuria
- Anorexia, nausea, vomiting, abdominal pain, diarrhea
- Tachycardia and palpitations
- Increased serum uric acid
Contre-indications
- Functional hypoglycemia
- Hypersensitivity to diazoxide, its excipients, or other thiazides
Précautions particulières
- Fluid retention from antidiuretic effect may precipitate congestive heart failure in patients with compromised cardiac reserve.
- Ketoacidosis and nonketotic hyperosmolar coma reported, usually during intercurrent illness; long half-life requires prolonged surveillance; patients should monitor urine glucose and ketones.
- Pulmonary hypertension reported in neonates and infants; monitor and discontinue if suspected.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (40)
- Alogliptin-metformin + Diazoxide Major
- Canagliflozin-metformin + Diazoxide Major
- Diazoxide + Empagliflozin-metformin Major
- Diazoxide + Glipizide-metformin Major
- Diazoxide + Glyburide-metformin Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-liraglutide Major
- Diazoxide + Linagliptin-metformin Major
- Diazoxide + Metformin-pioglitazone Major
- Diazoxide + Metformin-sitagliptin Major
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- Renal and hepatic dose adjustments
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Questions fréquentes
What is Diazoxide used for?
Diazoxide is a medicine in the class miscellaneous. It is used for Hypoglycemia.
What side effects have been reported with Diazoxide?
Sodium and fluid retention, Hirsutism (lanugo type), Hyperglycemia or glycosuria, Anorexia, nausea, vomiting, abdominal pain, diarrhea, Tachycardia and palpitations, Increased serum uric acid.
Can Diazoxide be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Case reports are too few to assess birth-defect risk. It crosses the placenta: use before delivery has caused high blood sugar, hair loss and excess body hair in newborns, and labels warn of jaundice and low platelets. Use only if the mother's benefit outweighs the risk. Breastfeeding: Unknown. Present in human milk; no data on infant effects or milk supply. US labels: weigh breastfeeding against the mother's need (older label: choose one). If used, monitor the infant's blood glucose, especially in the newborn period.
What does Diazoxide interact with?
MediHelp lists 40 known interactions for Diazoxide. Major: 10 · Moderate: 30. The most serious include Alogliptin-metformin, Canagliflozin-metformin, Empagliflozin-metformin.
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