Référentiel des médicaments
Famciclovir
Famciclovir is a medicine in the class anti virals. It is used for genital herpes.
- Classe médicamenteuse: Anti Virals
- Indications: genital herpes
Dernière mise à jour
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Le contenu clinique de cette page n'est disponible qu'en anglais.
L'essentiel
- Classe médicamenteuse
- Anti Virals
- Formes courantes
- comprimé
- Dosages courants
- 250 mg, 500 mg, 125 mg
- Interactions connues
- 10 (Majeure: 3 · Modérée: 1 · Mineure: 6)
- Noms commerciaux
- 17
- Pays et marchés
- 3
Indications
Mécanisme d'action
Prodrug of penciclovir, which selectively inhibits viral DNA replication in herpes simplex virus (HSV) type 1 (HSV-1), HSV-2, and varicella zoster virus (VZV)
Posologie adulte habituelle (résumé de la notice)
Acute Herpes Zoster (Shingles): 500 mg PO q8hr for 7 days; initiated within 72 hours of symptom or lesion onset
Grossesse et allaitement
- Grossesse
- Unknown Pharmacovigilance data have not shown a risk of birth defects or miscarriage, and animal studies showed no harm, but human data are limited. Aciclovir or valaciclovir, with far more pregnancy data, are preferred for herpes in pregnancy.
- Allaitement
- Unknown No human milk data; in rats milk levels were up to 8 times blood levels. US label: weigh benefits. LactMed: with no published experience, other agents such as aciclovir or valaciclovir may be preferred, especially with a newborn.
Effets indésirables signalés
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Flatulence
- Dysmenorrhea
Contre-indications
- Known hypersensitivity to this drug or its active metabolite, penciclovir
Principales interactions (10)
- Famciclovir + Talimogene laherparepvec Major
- Famciclovir + Varicella virus vaccine live Major
- Famciclovir + Zoster vaccine live Major
- Famciclovir + Tenofovir df Moderate
- Cimetidine + Famciclovir Minor
- Digoxin + Famciclovir Minor
- Famciclovir + Probenecid Minor
- Famciclovir + Raloxifene Minor
- Famciclovir + Tenofovir disoproxil Minor
- Famciclovir + Ublituximab Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Famciclovir used for?
Famciclovir is a medicine in the class anti virals. It is used for Genital herpes, Herpes simplex, Herpes zoster.
What side effects have been reported with Famciclovir?
Headache, Diarrhea, Nausea, Abdominal pain, Flatulence, Dysmenorrhea.
Can Famciclovir be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Pharmacovigilance data have not shown a risk of birth defects or miscarriage, and animal studies showed no harm, but human data are limited. Aciclovir or valaciclovir, with far more pregnancy data, are preferred for herpes in pregnancy. Breastfeeding: Unknown. No human milk data; in rats milk levels were up to 8 times blood levels. US label: weigh benefits. LactMed: with no published experience, other agents such as aciclovir or valaciclovir may be preferred, especially with a newborn.
What does Famciclovir interact with?
MediHelp lists 10 known interactions for Famciclovir. Major: 3 · Moderate: 1 · Minor: 6. The most serious include Talimogene laherparepvec, Varicella virus vaccine live, Zoster vaccine live.
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