Référentiel des médicaments
Flibanserin
Flibanserin is a medicine in the class genitourinary. It is used for hypoactive sexual desire disorder.
- Classe médicamenteuse: Genitourinary
- Indications: hypoactive sexual desire disorder
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Genitourinary
- Formes courantes
- comprimé
- Dosages courants
- 100 mg
- Interactions connues
- 278 (Contre-indiquée: 43 · Majeure: 52 · Modérée: 157 · Mineure: 26)
- Noms commerciaux
- 7
- Pays et marchés
- 2
Indications
Mécanisme d'action
Postsynaptic serotonin-1A (5HT-1A) receptor agonist and 5HT-2A receptor antagonist; also elicits moderate antagonist activities at the 5-HT2B, 5-HT2C, and dopamine D4 receptors.
Posologie adulte habituelle (résumé de la notice)
Hypoactive Sexual Desire Disorder: 100 mg PO once daily at bedtime
Grossesse et allaitement
- Grossesse
- Unknown No studies in pregnant women. In rats and rabbits, fetal harm occurred only at more than 15 times human exposure with maternal toxicity. It is for premenopausal women with low sexual desire; stop if pregnancy occurs.
- Allaitement
- Unsafe Not known whether it passes into human milk; it does into rat milk. LactMed: high protein binding suggests low milk levels. US label: not recommended while breastfeeding because of possible serious effects, including sedation, in the infant.
Effets indésirables signalés
- Fatigue
- Nausea
- Insomnia
- Somnolence
- Dizziness
Contre-indications
- Coadministration with moderate or strong CYP3A4 inhibitors
- Hepatic impairment
- Known hypersensitivity to drug or excipients
Précautions particulières
- Coadministration with moderate or strong CYP3A4 inhibitors increases flibanserin concentrations, which can cause severe hypotension and syncope.
- Hypersensitivity reactions, including anaphylaxis, reactions consistent with angioedema (eg, swelling of the face, lips, and mouth), pruritus, and urticaria reported.
- Flibanserin may increase blood concentrations of P-gp substrates (eg, digoxin, sirolimus).
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (278)
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
- Cyclosporin + Flibanserin Contraindicated
- Cyclosporine + Flibanserin Contraindicated
- Darunavir + Flibanserin Contraindicated
- Diltiazem + Flibanserin Contraindicated
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
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- Food interactions
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Questions fréquentes
What is Flibanserin used for?
Flibanserin is a medicine in the class genitourinary. It is used for Hypoactive sexual desire disorder.
What side effects have been reported with Flibanserin?
Fatigue, Nausea, Insomnia, Somnolence, Dizziness.
Can Flibanserin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No studies in pregnant women. In rats and rabbits, fetal harm occurred only at more than 15 times human exposure with maternal toxicity. It is for premenopausal women with low sexual desire; stop if pregnancy occurs. Breastfeeding: Unsafe. Not known whether it passes into human milk; it does into rat milk. LactMed: high protein binding suggests low milk levels. US label: not recommended while breastfeeding because of possible serious effects, including sedation, in the infant.
What does Flibanserin interact with?
MediHelp lists 278 known interactions for Flibanserin. Contraindicated: 43 · Major: 52 · Moderate: 157 · Minor: 26. The most serious include Atazanavir, Ceritinib, Clarithromycin.
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