Référentiel des médicaments
Ibandronate
Ibandronate is a medicine in the class musculoskeletal. It is used for osteoporosis.
- Classe médicamenteuse: Musculoskeletal
- Indications: osteoporosis
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Musculoskeletal
- Code ATC
- M05BA06
- Formes courantes
- comprimé, injection
- Dosages courants
- 150 mg, 3.375 mg/3 ml, 6 mg/6 ml
- Interactions connues
- 33 (Modérée: 32 · Mineure: 1)
- Noms commerciaux
- 13
- Pays et marchés
- 4
Indications
Mécanisme d'action
Bisphosphonate which inhibits bone resorption via actions on osteoclast activity, leading to an indirect increase in bone density.
Posologie adulte habituelle (résumé de la notice)
150 mg PO every month
Grossesse et allaitement
- Grossesse
- Unsafe Not for use in pregnancy (postmenopausal osteoporosis). Bisphosphonates stay in bone for years and may affect fetal bone and calcium; in rats, ibandronate caused embryo loss, difficult labour and kidney effects in offspring. Limited human data show no clear defect pattern.
- Allaitement
- Unknown Not indicated in women who could breastfeed; no milk data (present in rat milk). LactMed: very poorly absorbed orally, so infant absorption is unlikely, but an alternative may be preferred, especially with a newborn.
Effets indésirables signalés
- Diarrhea
- URI
- Dyspepsia
- Asthenia
- Back pain
- Bronchitis
Contre-indications
- Hypersensitivity; anaphylaxis reported, including fatalities
- Uncorrected hypocalcemia
- Inability to stand or sit upright for at least 60 min
Précautions particulières
- Potential for esophagitis, dysphagia & esophageal ulcers
- Severe esophageal risk greater in patients who lie down after taking oral bisphosphonates and/or who fail to swallow it with the recommended full glass (6-8 oz) of water
- Ensure adequate intake of calcium, vitamin D; correct hypocalcemia before use
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (33)
- Aluminum hydroxide + Ibandronate Moderate
- Calcium + Ibandronate Moderate
- Calcium acetate + Ibandronate Moderate
- Calcium carbonate + Ibandronate Moderate
- Calcium chloride + Ibandronate Moderate
- Calcium citrate + Ibandronate Moderate
- Calcium gluconate + Ibandronate Moderate
- Carbonyl iron + Ibandronate Moderate
- Deferasirox + Ibandronate Moderate
- Ferric maltol + Ibandronate Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Ibandronate used for?
Ibandronate is a medicine in the class musculoskeletal. It is used for Osteoporosis.
What side effects have been reported with Ibandronate?
Diarrhea, URI, Dyspepsia, Asthenia, Back pain, Bronchitis.
Can Ibandronate be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Not for use in pregnancy (postmenopausal osteoporosis). Bisphosphonates stay in bone for years and may affect fetal bone and calcium; in rats, ibandronate caused embryo loss, difficult labour and kidney effects in offspring. Limited human data show no clear defect pattern. Breastfeeding: Unknown. Not indicated in women who could breastfeed; no milk data (present in rat milk). LactMed: very poorly absorbed orally, so infant absorption is unlikely, but an alternative may be preferred, especially with a newborn.
What does Ibandronate interact with?
MediHelp lists 33 known interactions for Ibandronate. Moderate: 32 · Minor: 1. The most serious include Aluminum hydroxide, Calcium, Calcium acetate.
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