Référentiel des médicaments
Zoledronic acid
Zoledronic acid is a medicine in the class musculoskeletal. It is used for glucocorticoid-induced osteoporosis.
- Classe médicamenteuse: Musculoskeletal
- Indications: glucocorticoid-induced osteoporosis
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Musculoskeletal
- Code ATC
- M05BA08
- Formes courantes
- injection, perfusion
- Dosages courants
- 4 mg/5 ml, 5 mg/100 ml, 4 mg
- Interactions connues
- 19 (Modérée: 13 · Mineure: 6)
- Noms commerciaux
- 37
- Pays et marchés
- 5
Indications
Mécanisme d'action
Bisphosphonate; inhibits bone resorption via actions on osteoclast activity, leading to indirect increase in bone density
Posologie adulte habituelle (résumé de la notice)
Hypercalcemia of Malignancy (Zometa): No more than 4 mg IV (infused over >15 minutes) once; may be repeated in 7 days
Grossesse et allaitement
- Grossesse
- Unsafe No human data. In rats it caused malformations and fetal loss at about 2 times human exposure. It is stored in bone for years, so a later pregnancy may also be exposed. EU label: contraindicated in pregnancy and not recommended in women who could conceive; US: stop when pregnancy is recognised.
- Allaitement
- Unknown No data on passage into milk; infant absorption is unlikely (LactMed). EU (Aclasta): contraindicated while breastfeeding; US oncology labels: do not breastfeed during and after treatment (bone retention); Reclast: weigh benefits. LactMed: prefer an alternative, especially with a newborn.
Effets indésirables signalés
- Fatigue
- Vomiting
- Nausea
- Constipation
- Anemia
- Bone pain
Contre-indications
- Pregnancy
- All indications: Hypersensitivity, including rare cases of urticaria, angioedema, and anaphylactic reaction or shock
- Nononcologic uses: Hypocalcemia, severe renal impairment (CrCl <35 mL/min or evidence of acute renal impairment)
Précautions particulières
- Infuse over ≥15 minutes; faster infusion increases renal toxicity
- Increased risk of osteonecrosis of jaw (advise patients against dental work); reported predominantly in cancer patients treated with IV bisphosphonates
- Risk of osteonecrosis of the jaw may increase with duration of exposure to bisphosphonates
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (19)
- Amikacin + Zoledronic acid Moderate
- Bumetanide + Zoledronic acid Moderate
- Dichlorphenamide + Zoledronic acid Moderate
- Ethacrynic acid + Zoledronic acid Moderate
- Foscarnet + Zoledronic acid Moderate
- Gentamicin + Zoledronic acid Moderate
- Human parathyroid hormone recombinant + Zoledronic acid Moderate
- Indomethacin + Zoledronic acid Moderate
- Sodium sulfate / ?magnesium sulfate / potassium chloride + Zoledronic acid Moderate
- Sodium sulfate / potassium sulfate / magnesium sulfate + Zoledronic acid Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Lectures rapides associées
Questions fréquentes
What is Zoledronic acid used for?
Zoledronic acid is a medicine in the class musculoskeletal. It is used for Glucocorticoid-induced osteoporosis, Hypercalcemia of malignancy, Osteoporosis, Paget's disease.
What side effects have been reported with Zoledronic acid?
Fatigue, Vomiting, Nausea, Constipation, Anemia, Bone pain.
Can Zoledronic acid be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. No human data. In rats it caused malformations and fetal loss at about 2 times human exposure. It is stored in bone for years, so a later pregnancy may also be exposed. EU label: contraindicated in pregnancy and not recommended in women who could conceive; US: stop when pregnancy is recognised. Breastfeeding: Unknown. No data on passage into milk; infant absorption is unlikely (LactMed). EU (Aclasta): contraindicated while breastfeeding; US oncology labels: do not breastfeed during and after treatment (bone retention); Reclast: weigh benefits. LactMed: prefer an alternative, especially with a newborn.
What does Zoledronic acid interact with?
MediHelp lists 19 known interactions for Zoledronic acid. Moderate: 13 · Minor: 6. The most serious include Amikacin, Bumetanide, Dichlorphenamide.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
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